Food Workers as a Reservoir of Extended-Spectrum-Cephalosporin-Resistant Salmonella Strains in Japan-Reference-Cited by-同舟云学术

Food Workers as a Reservoir of Extended-Spectrum-Cephalosporin-Resistant Salmonella Strains in Japan

Published:2020-06-17 Issue:13 Volume:86 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Shigemura Hiroaki¹,Sakatsume Eri²,Sekizuka Tsuyoshi³,Yokoyama Hiroshi²,Hamada Kunihiko²,Etoh Yoshiki¹,Carle Yuki¹,Mizumoto Shiro⁴,Hirai Shinichiro⁵,Matsui Mari⁶,Kimura Hirokazu⁷,Suzuki Motoi⁵,Onozuka Daisuke⁸,Kuroda Makoto³^ORCID,Inoshima Yasuo⁹,Murakami Koichi⁵

Affiliation:

1. Division of Pathology and Microbiology, Department of Health Science, Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan

2. Kotobiken Medical Laboratories, Inc., Fukushima, Japan

3. Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan

4. Department of Microbiology, Shizuoka Institute of Environment and Hygiene, Shizuoka, Japan

5. Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan

6. Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan

7. School of Medical Technology, Faculty of Health Science, Gunma Paz University, Gunma, Japan

8. Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan

9. Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan

Abstract

Antimicrobial-resistant Salmonella bacteria arise in farm environments through imprudent use of antimicrobials. Subsequently, these antimicrobial-resistant strains, such as extended-spectrum-β-lactamase (ESBL)-producing Salmonella , may be transmitted to humans via food animal-derived products. Here, we examined Salmonella carriage among food handlers in Japan. Overall, 164 of 145,220 fecal samples (0.113%) were positive for Salmonella . Among the 158 tested isolates, four were identified as ESBL-producing isolates carrying ESBL determinants bla CTX-M-15 or bla CTX-M-14 . In all cases, the genes coexisted with IS Ecp1 , regardless of whether they were located on the chromosome or on a plasmid. Our findings suggest that food workers may be a reservoir of ESBL-producing strains and could contribute to the spread of resistance genes from farm-derived Salmonella to other bacterial species present in the human gut.

Funder

The Japan Society for the Promotion of Sciences KAKENHI

The Japan Agency for Medical Research and Development, AMED

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00072-20

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