Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome-Reference-Cited by-同舟云学术

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome

Published:2021-07-12 Issue:15 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Barbosa Jérémy A. Ferreira¹,Sparapani Samantha¹,Boulais Jonathan¹,Lodge Robert¹,Cohen Éric A.¹²^ORCID

Affiliation:

1. Montreal Clinical Research Institute, Montréal, Québec, Canada

2. Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, Québec, Canada

Abstract

The function of the Vpr accessory protein during HIV-1 infection remains poorly defined. Several cellular targets of Vpr were previously identified, but their individual degradation does not fully explain the ability of Vpr to impair the cell cycle or promote HIV-1 replication in macrophages.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00971-20

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