Evaluation of Artemisone Combinations in Aotus Monkeys Infected with Plasmodium falciparum-Reference-Cited by-同舟云学术

Evaluation of Artemisone Combinations in Aotus Monkeys Infected with Plasmodium falciparum

Published:2009-08 Issue:8 Volume:53 Page:3592-3594
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Obaldia Nicanor¹,Kotecka Barbara M.²,Edstein Michael D.²,Haynes Richard K.³,Fugmann Burkhard⁴,Kyle Dennis E.²,Rieckmann Karl H.²

Affiliation:

1. Tropical Medicine Research, Malaria Drug and Vaccine Evaluation Center/Gorgas Memorial Institute of Health Studies, Panama, Panama

2. Australian Army Malaria Institute, Brisbane, Australia

3. Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong University of Science and Technology, Kowloon, Hong Kong

4. Bayer Innovation, Düsseldorf, Germany

Abstract

ABSTRACT Artemisone (single oral dose, 10 mg/kg of body weight) cured nonimmune Aotus monkeys of their Plasmodium falciparum infections when combined with mefloquine (single oral dose, 5 and 10 mg/kg but not 2.5 mg/kg). In combination with amodiaquine (20 mg/kg/day), artemisone (10 mg/kg/day) given orally for 3 days cured all infected monkeys. Three days of treatment with artemisone (30 mg/kg/day) and clindamycin (100 mg/kg/day) was also curative.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00471-09

Reference25 articles.

1. Adjuik, M., A. Babiker, P. Garner, P. Olliaro, W. Taylor, and N. White. 2004. Artesunate combinations for treatment of malaria: meta-analysis. Lancet363:9-17.

2. Brewer, T. G., J. O. Peggins, S. J. Grate, J. M. Petras, B. S. Levine, P. J. Weina, J. Swearengen, M. H. Heiffer, and B. G. Schuster. 1994. Neurotoxicity in animals due to arteether and artemether. Trans. R. Soc. Trop. Med. Hyg.88(Suppl. 1):S33-S36.

3. Brockman, A., R. N. Price, M. van Vugt, D. G. Heppner, D. Walsh, P. Sookto, T. Wimonwattrawatee, S. Looareesuwan, N. J. White, and F. Nosten. 2000. Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine. Trans. R. Soc. Trop. Med. Hyg.94:537-544.

4. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

5. Freireich, E. J., E. A. Gehan, D. P. Rall, L. H. Schmidt, and H. E. Skipper. 1966. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother. Rep.50:219-244.

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