A Novel cis Regulatory Element Regulates Human XIST in a CTCF-Dependent Manner-Reference-Cited by-同舟云学术

A Novel cis Regulatory Element Regulates Human XIST in a CTCF-Dependent Manner

Published:2021-07-23 Issue:8 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Shah Rini¹^ORCID,Sharma Ankita¹^ORCID,Kelkar Ashwin¹^ORCID,Sengupta Kundan²^ORCID,Galande Sanjeev¹^ORCID

Affiliation:

1. Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research, Pune, India

2. Chromosome Biology Laboratory, Department of Biology, Indian Institute of Science Education and Research, Pune, India

Abstract

The long noncoding RNA XIST is the master regulator for the process of X chromosome inactivation (XCI) in mammalian females. Here, we report the existence of a hitherto-uncharacterized cis regulatory element (cRE) within the first exon of human XIST , which determines the transcriptional status of XIST during the initiation and maintenance phases of XCI.

Funder

The Wellcome Trust DBT India Alliance

DST | Science and Engineering Research Board

Department of Biotechnology, Ministry of Science and Technology, India

University Grants Commission

Council of Scientific and Industrial Research

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00382-20