Generation and Molecular Characterization of Human Ring Sideroblasts: a Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation-Reference-Cited by-同舟云学术

Generation and Molecular Characterization of Human Ring Sideroblasts: a Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation

Published:2019-04 Issue:7 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Saito Kei¹,Fujiwara Tohru¹,Hatta Shunsuke¹,Morita Masanobu²,Ono Koya¹,Suzuki Chie¹³,Fukuhara Noriko¹,Onishi Yasushi¹,Nakamura Yukio⁴,Kawamata Shin⁵,Shimizu Ritsuko⁶,Yamamoto Masayuki²⁷,Harigae Hideo¹

Affiliation:

1. Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

2. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

3. Department of Laboratory, Tohoku University Hospital, Sendai, Japan

4. Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan

5. Division of Cell Therapy, Foundation of Biomedical Research and Innovation, Kobe, Japan

6. Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan

7. Tohoku Medical Magabank Organization, Tohoku University, Sendai, Japan

Abstract

Ring sideroblasts are a hallmark of sideroblastic anemia, although little is known about their characteristics. Here, we first generated mutant mice by disrupting the GATA-1 binding motif at the intron 1 enhancer of the ALAS2 gene, a gene responsible for X-linked sideroblastic anemia (XLSA).

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00387-18

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