Secretion into Milk of the Main Metabolites of the Anthelmintic Albendazole Is Mediated by the ABCG2/BCRP Transporter-Reference-Cited by-同舟云学术

Secretion into Milk of the Main Metabolites of the Anthelmintic Albendazole Is Mediated by the ABCG2/BCRP Transporter

Published:2022-07-19 Issue:7 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Blanco-Paniagua Esther¹²,Álvarez- Fernández Laura¹²,Garcia-Lino Alba M.¹²,Álvarez Ana I.¹²,Merino Gracia¹²^ORCID

Affiliation:

1. Departamento de Ciencias Biomédicas-Fisiología, Facultad de Veterinaria, Universidad de León, León, Spain

2. Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain

Abstract

Albendazole (ABZ) is an anthelmintic with a broad-spectrum activity, widely used in human and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO 2 ) and albendazole 2-aminosulphone (ABZSO 2 -NH 2 ).

Funder

Ministerio de Educación y Formación Profesional

Ministerio de Ciencia, Innovación y Universidades

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00062-22

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