Increasing Incidence of Linezolid-Intermediate or -Resistant, Vancomycin-Resistant Enterococcus faecium Strains Parallels Increasing Linezolid Consumption-Reference-Cited by-同舟云学术

Increasing Incidence of Linezolid-Intermediate or -Resistant, Vancomycin-Resistant Enterococcus faecium Strains Parallels Increasing Linezolid Consumption

Published:2008-06 Issue:6 Volume:52 Page:2256-2259
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Scheetz Marc H.¹²,Knechtel Stephanie A.²,Malczynski Michael³,Postelnick Michael J.²,Qi Chao³

Affiliation:

1. Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, Chicago, Illinois

2. Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois

3. Department of Pathology, Clinical Microbiology Division, Northwestern Memorial Hospital, Chicago, Illinois

Abstract

ABSTRACT Clinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found ( r 2 = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00070-08

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