Absence of Amphotericin B-Tolerant Persister Cells in Biofilms of Some Candida Species-Reference-Cited by-同舟云学术

Absence of Amphotericin B-Tolerant Persister Cells in Biofilms of Some Candida Species

Published:2008-05 Issue:5 Volume:52 Page:1884-1887
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Al-Dhaheri Rawya S.¹,Douglas L. Julia¹

Affiliation:

1. Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom

Abstract

ABSTRACT Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential or stationary phase) contained persister cells. However, persisters were found in biofilms of one of two strains of Candida albicans tested and in biofilms of Candida krusei and Candida parapsilosis , but not in biofilms of Candida glabrata or Candida tropicalis . These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01473-07

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