Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus-Reference-Cited by-同舟云学术

Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus

Published:1990-02 Issue:2 Volume:64 Page:664-671
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

de la Torre J C¹,Wimmer E¹,Holland J J¹

Affiliation:

1. Institute of Molecular Genetics, University of California, San Diego, La Jolla 92093.

Abstract

We have carefully examined the frequency of guanidine-resistant revertants in six different clonal pools of guanidine-dependent mutants of type 1 poliovirus. The mutation frequency was (6.5 +/- 6.3) x 10(-4) (with all amino acid substitutions occurring at position 227). The minimal corrected base substitution frequency per single nucleotide site in the codon for amino acid 227 was (2.1 +/- 1.9) x 10(-4).

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.64.2.664-671.1990

Reference13 articles.

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5. Action of guanidine on the replication of poliovirus RNA;Caliguiri L. A.;Virology,1968

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