Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen-Reference-Cited by-同舟云学术

Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen

Published:2022-07-13 Issue:13 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pedersen Savannah F.¹,Collora Jack A.¹,Kim Rachel N.¹,Yang Kerui¹,Razmi Anya¹,Catalano Allison A.¹,Yeh Yang-Hui Jimmy¹,Mounzer Karam²,Tebas Pablo³,Montaner Luis J.⁴,Ho Ya-Chi¹^ORCID

Affiliation:

1. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA

2. Philadelphia FIGHT Community Health Centers, Philadelphia, Pennsylvania, USA

3. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. The Wistar Institute, Philadelphia, Pennsylvania, USA

Abstract

HIV-1-infected cells, which can survive drug treatment and immune cell killing, prevent an HIV-1 cure. Immune recognition of infected cells requires HIV-1 protein expression; however, HIV-1 protein expression is limited in infected cells after long-term therapy.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute on Drug Abuse

National Institute of Development Administration

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00577-22

Reference74 articles.