Substrate specificity of Epstein-Barr virus thymidine kinase-Reference-Cited by-同舟云学术

Substrate specificity of Epstein-Barr virus thymidine kinase

Published:1994-09 Issue:9 Volume:38 Page:2175-2179
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tung P P¹,Summers W C¹

Affiliation:

1. Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520-8040.

Abstract

Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovir and dihydroxypropylmethylguanine are relatively poor substrates for the Epstein-Barr virus thymidine kinase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.38.9.2175

Reference27 articles.

1. Effect of acyclovir on infectious mononucleosis: a double-blind, placebo-controlled study;Andersson J.;J. Infect. Dis.,1986

2. Management of Epstein-Barr virus infections;Andersson J.;Am. J. Med.,1988

3. DNA sequence and expression of the B95-8 Epstein-Barr virus genome;Baer R;Nature (London),1984

4. Kinetic studies of herpes simplex virus type I-encoded thymidine and thymidylate kinase, a multifunctional enzyme;Chen M. S.;J. Biol. Chem.,1979

5. Deoxythymidine kinase induced in HeLa TKcells by herpes simplex virus type I and type 2. II. Substrate specificity and substrate behaviours;Cheng Y. C.;Biochim. Biophys. Acta,1976

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recombinant Human Interferon-Gamma: Prospects for the Treatment of Chronic Epstein-Barr Viral Infection;Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control;2022-01-12

2. Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra;Drug Resistance Updates;2018-03

3. Valganciclovir for the Suppression of Epstein-Barr Virus Replication;The Journal of Infectious Diseases;2017-05-30

4. Spectrum of Activity and Mechanisms of Resistance of Various Nucleoside Derivatives against Gammaherpesviruses;Antimicrobial Agents and Chemotherapy;2014-09-29

5. Activity and Mechanism of Action of HDVD, a Novel Pyrimidine Nucleoside Derivative with High Levels of Selectivity and Potency against Gammaherpesviruses;Journal of Virology;2013-01-23