Outer Membrane Vesicles Derived from Salmonella enterica Serotype Typhimurium Can Deliver Shigella flexneri 2a O-Polysaccharide Antigen To Prevent Shigella flexneri 2a Infection in Mice

Author:

Tian Huizhen1,Li Biaoxian1,Xu Tian1,Yu Haolin2,Chen Jingxuan2,Yu Haiyan1,Li Shan1,Zeng Lingbing3,Huang Xiaotian1,Liu Qiong14ORCID

Affiliation:

1. Department of Medical Microbiology, School of Medicine, Nanchang University, Nanchang, China

2. School of Ophthalmology and Optometry, Nanchang University, Nanchang, China

3. The First Affiliated Hospital of Nanchang University, Nanchang, China

4. Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

Abstract

Shigella , the cause of shigellosis or bacillary dysentery, is a major public health concern, especially for children in developing countries. An effective vaccine would control the spread of the disease to some extent.

Funder

The Science and Technology Research Project of Jiangxi Provincial Education Department

Key research and development projects of Jiangxi Natural Science Foundation

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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