Large Clostridial Toxins: Mechanisms and Roles in Disease-Reference-Cited by-同舟云学术

Large Clostridial Toxins: Mechanisms and Roles in Disease

Published:2021-08-18 Issue:3 Volume:85 Page:
ISSN:1092-2172
Container-title:Microbiology and Molecular Biology Reviews
language:en
Short-container-title:Microbiol Mol Biol Rev

Author:

Orrell Kathleen E.¹²^ORCID,Melnyk Roman A.¹²^ORCID

Affiliation:

1. Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada

2. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Abstract

Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB, Paeniclostridium sordellii toxins TcsL and TcsH, Clostridium novyi toxin TcnA, and Clostridium perfringens toxin TpeL.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

Link

https://journals.asm.org/doi/pdf/10.1128/MMBR.00064-21

Reference293 articles.

1. The pore structure of Clostridium perfringens epsilon toxin

2. Clostridium difficilebinary toxin CDT