A Potent and Effective Suicidal Listeria Vaccine Platform-Reference-Cited by-同舟云学术

A Potent and Effective Suicidal Listeria Vaccine Platform

Published:2019-08 Issue:8 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hanson William G.¹,Benanti Erin L.¹,Lemmens Edward E.¹,Liu Weiqun¹,Skoble Justin¹,Leong Meredith L.¹,Rae Chris S.¹,Fassò Marcella¹,Brockstedt Dirk G.¹,Chen Chen²³,Portnoy Daniel A.²³,Dubensky Thomas W.¹,Lauer Peter¹

Affiliation:

1. Aduro Biotech, Inc., Berkeley, California, USA

2. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA

3. Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA

Abstract

Live-attenuated Listeria monocytogenes has shown encouraging potential as an immunotherapy platform in preclinical and clinical settings. However, additional safety measures will enable application across malignant and infectious diseases. Here, we describe a new vaccine platform, termed Lm-RIID ( L. monocytogenes recombinase-induced intracellular death), that induces the deletion of genes required for bacterial viability yet maintains potent T cell responses to encoded antigens.

Funder

Aduro Biotech

DOD | Small Business Innovation Research

HHS | National Institutes of Health

Aduro Biotech Immunotherapeutics and Vaccine Research Initiative

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00144-19

Reference48 articles.