Evidence for Recombination of Live, Attenuated Immunodeficiency Virus Vaccine with Challenge Virus to a More Virulent Strain-Reference-Cited by-同舟云学术

Evidence for Recombination of Live, Attenuated Immunodeficiency Virus Vaccine with Challenge Virus to a More Virulent Strain

Published:2000-04-15 Issue:8 Volume:74 Page:3537-3542
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gundlach Björn R.¹,Lewis Mark G.²,Sopper Sieghart³,Schnell Tanja¹,Sodroski Joseph⁴,Stahl-Hennig Christiane⁵,Überla Klaus¹⁶

Affiliation:

1. Institut für Virologie, Universität Erlangen-Nürnberg, Erlangen,1

2. Henry M. Jackson Foundation, Rockville, Maryland2; and

3. Institut für Virologie und Immunobiologie, Universität Würzburg, Würzburg,3

4. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts4

5. Deutsches Primatenzentrum, Göttingen,5 and

6. Institut für Virologie, Universität Leipzig, Leipzig,6 Germany;

Abstract

ABSTRACT Live, attenuated immunodeficiency virus vaccines, such as nef deletion mutants, are the most effective vaccines tested in the simian immunodeficiency virus (SIV) macaque model. In two independent studies designed to determine the breadth of protection induced by live, attenuated SIV vaccines, we noticed that three of the vaccinated macaques developed higher set point viral load levels than unvaccinated control monkeys. Two of these vaccinated monkeys developed AIDS, while the control monkeys infected in parallel remained asymptomatic. Concomitant with an increase in viral load, a recombinant of the vaccine virus and the challenge virus could be detected. Therefore, the emergence of more-virulent recombinants of live, attenuated immunodeficiency viruses and less-aggressive wild-type viruses seems to be an additional risk of live, attenuated immunodeficiency virus vaccines.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.8.3537-3542.2000

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