A Novel Subgenomic Murine Leukemia Virus RNA Transcript Results from Alternative Splicing-Reference-Cited by-同舟云学术

A Novel Subgenomic Murine Leukemia Virus RNA Transcript Results from Alternative Splicing

Published:2000-04-15 Issue:8 Volume:74 Page:3709-3714
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Déjardin Jérôme¹,Bompard-Maréchal Guillaume¹,Audit Muriel¹,Hope Thomas J.²,Sitbon Marc¹,Mougel Marylène¹

Affiliation:

1. Institut de Génétique Moléculaire de Montpellier, IFR 24, CNRS-UMR5535, and Université Montpellier II, F-34293 Montpellier Cedex 5, France,1 and

2. Salk Institute for Biological Studies, La Jolla, California 920372

Abstract

ABSTRACT Here we show the existence of a novel subgenomic 4.4-kb RNA in cells infected with the prototypic replication-competent Friend or Moloney murine leukemia viruses (MuLV). This RNA derives by splicing from an alternative donor site (SD′) within the capsid-coding region to the canonical envelope splice acceptor site. The position and the sequence of SD′ was highly conserved among mammalian type C and D oncoviruses. Point mutations used to inactivate SD′ without changing the capsid-coding ability affected viral RNA splicing and reduced viral replication in infected cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.8.3709-3714.2000

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