The Efficiency of p27 Cleavage during <i>In Vitro</i> Respiratory Syncytial Virus (RSV) Infection Is Cell Line and RSV Subtype Dependent-Reference-Cited by-同舟云学术

The Efficiency of p27 Cleavage during In Vitro Respiratory Syncytial Virus (RSV) Infection Is Cell Line and RSV Subtype Dependent

Published:2023-05-31 Issue:5 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rezende Wanderson¹²^ORCID,Ye Xunyan¹³^ORCID,Angelo Laura S.¹,Carisey Alexandre F.⁴^ORCID,Avadhanula Vasanthi¹,Piedra Pedro A.¹⁵^ORCID

Affiliation:

1. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

2. Department of Pharmacology, Baylor College of Medicine, Houston, Texas, USA

3. Avance Biosciences, Houston, Texas, USA

4. William T. Shearer Center for Human Immunology, Texas Children’s Hospital, Houston, Texas, USA

5. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA

Abstract

RSV fusion protein (F) plays an important role in entry and viral fusion to the host cell. The F undergoes proteolytic cleavages releasing a 27-amino-acid peptide (p27) to become fully functional.

Funder

Discretionary funds

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00254-23

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