Agglutination of Borreliella burgdorferi by Transmission-Blocking OspA Monoclonal Antibodies and Monovalent Fab Fragments-Reference-Cited by-同舟云学术

Agglutination of Borreliella burgdorferi by Transmission-Blocking OspA Monoclonal Antibodies and Monovalent Fab Fragments

Published:2022-09-15 Issue:9 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Frye Amber M.¹,Ejemel Monir²,Cavacini Lisa²,Wang Yang²,Rudolph Michael J.³,Song Renjie⁴,Mantis Nicholas J.¹⁴^ORCID

Affiliation:

1. Department of Biomedical Sciences, University at Albany, Albany, New York, USA

2. MassBiologics, Boston, Massachusetts, USA

3. New York Structural Biology Center, New York, New York, USA

4. Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA

Abstract

Lyme disease vaccines based on recombinantOutersurfaceprotein A (OspA) elicit protective antibodies that interfere with tick-to-host transmission of the disease-causing spirocheteBorreliella burgdorferi. Another hallmark of OspA antisera and certain OspA monoclonal antibodies (MAbs) is their capacity to induceB. burgdorferiagglutinationin vitro, a phenomenon first reported more than 30 years ago but never studied in molecular detail.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00306-22

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