Fate of conidia of Paracoccidioides brasiliensis after ingestion by resident macrophages or cytokine-treated macrophages

Author:

Cano L E1,Brummer E1,Stevens D A1,Restrepo A1

Affiliation:

1. Corporacion para Investigaciones Biologicas, Hospital Pablo Tobon Uribe, Medellin, Colombia.

Abstract

Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice significantly inhibited transformation of ingested conidia.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference14 articles.

1. Fungicidal activation of murine macrophages by recombinant gamma interferon;Beaman L.;Infect. Immun.,1987

2. Activation of macrophages by Iymphokines: enhancement of phagosomelysosome fusion and killing of Coccidioides immitis;Beaman L.;Infect. Immun.,1983

3. In vivo and in vitro activation of pulmonary macrophages by IFN-gamma for enhanced killing of Paracoccidioides brasiliensis or Blastomyces dennatitidis;Brummer E.;J. Immunol.,1988

4. Intracellular multiplication of Paracoccidioides brasiliensis in macrophages: killing and restriction of multiplication by activated macrophages;Brummer E.;Infect. Immun.,1989

5. Ultrastructure of phagocytosed Paracoccidioides brasiliensis in nonactivated or activated macrophages;Brummer E.;Infect. Immun.,1990

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