Cell Division Inhibition in Salmonella typhimurium Histidine-Constitutive Strains: an ftsI -Like Defect in the Presence of Wild-Type Penicillin-Binding Protein 3 Levels

Author:

Cano David A.1,Mouslim Chakib1,Ayala Juan A.2,García-del Portillo Francisco2,Casadesús Josep1

Affiliation:

1. Departamento de Genética, Facultad de Biologı́a, Universidad de Sevilla, Seville 41080,1 and

2. Centro de Biologı́a Molecular Severo Ochoa, CSIC-Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049,2 Spain

Abstract

ABSTRACT Histidine-constitutive (His c ) strains of Salmonella typhimurium undergo cell division inhibition in the presence of high concentrations of a metabolizable carbon source. Filaments formed by His c strains show constrictions and contain evenly spaced nucleoids, suggesting a defect in septum formation. Inhibitors of penicillin-binding protein 3 (PBP3) induce a filamentation pattern identical to that of His c strains. However, the His c septation defect is caused neither by reduced PBP3 synthesis nor by reduced PBP3 activity. Gross modifications of peptidoglycan composition are also ruled out. d -Cycloserine, an inhibitor of the soluble pathway producing peptidoglycan precursors, causes phenotypic suppression of filamentation, suggesting that the septation defect of His c strains may be caused by scarcity of PBP3 substrate.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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