Polymorphism in Plasmodium falciparum Drug Transporter Proteins and Reversal of In Vitro Chloroquine Resistance by a 9,10-Dihydroethanoanthracene Derivative-Reference-Cited by-同舟云学术

Polymorphism in Plasmodium falciparum Drug Transporter Proteins and Reversal of In Vitro Chloroquine Resistance by a 9,10-Dihydroethanoanthracene Derivative

Published:2004-12 Issue:12 Volume:48 Page:4869-4872
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Millet Julie¹²,Alibert Sandrine³²,Torrentino-Madamet Marylin¹²,Rogier Christophe¹²,Santelli-Rouvier Christiane³²,Bigot Patricia¹²,Mosnier Joel¹²,Baret Eric¹²,Barbe Jacques³²,Parzy Daniel¹²,Pradines Bruno¹³

Affiliation:

1. Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées

2. Institut Fédératif de la Recherche 48

3. GERCTOP-UMR CNRS 6009, Faculté de Pharmacie

Abstract

ABSTRACT BG958 reverses resistance in chloroquine-resistant isolates from different countries. Five mutations in the Plasmodium falciparum crt ( pfcrt ) gene resulting in the amino acid changes K76T, M74I, N75E, A220S, and R371I are systematically identified in resistance-reversed Asian, African, and Brazilian parasites which possess the pfcrt (CIET) haplotype. In combination with BG958, the activity of chloroquine is increased in parasites with the N86Y mutation in pfmdr1 .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.12.4869-4872.2004

Reference33 articles.

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