Comparison of a Novel, Rapid Chromogenic Biochemical Assay, the Carba NP Test, with the Modified Hodge Test for Detection of Carbapenemase-Producing Gram-Negative Bacilli-Reference-Cited by-同舟云学术

Comparison of a Novel, Rapid Chromogenic Biochemical Assay, the Carba NP Test, with the Modified Hodge Test for Detection of Carbapenemase-Producing Gram-Negative Bacilli

Published:2013-09 Issue:9 Volume:51 Page:3097-3101
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Vasoo Shawn¹,Cunningham Scott A.¹,Kohner Peggy C.¹,Simner Patricia J.¹,Mandrekar Jayawant N.²,Lolans Karen³,Hayden Mary K.³⁴,Patel Robin¹⁵

Affiliation:

1. Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

2. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA

3. Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA

4. Section of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA

5. Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA

Abstract

ABSTRACT We compared carbapenemase detection among 271 Gram-negative bacilli (of which 131 were carbapenemase producers) using a novel chromogenic rapid test—the Carba NP test (CNP)—and the modified Hodge test (MHT). Sensitivities were comparable (CNP, 100%, versus MHT, 98%; P = 0.08), but CNP was more specific (100% versus 80%; P < 0.0001) and faster.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00965-13

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