In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate-Reference-Cited by-同舟云学术

In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate

Published:2007-12 Issue:12 Volume:51 Page:4505-4507
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Carson Kerry C.¹,Bartlett Jessica G.¹,Tan Trina-Jean¹,Riley Thomas V.¹²

Affiliation:

1. Microbiology and Infectious Disease, PathWest Laboratory Medicine WA

2. Microbiology and Immunology, The University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia

Abstract

ABSTRACT The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (≥1 h) were seen at 2× MIC and 4× MIC. The frequency of mutation was <10 −9 , and serial passage could not extend growth beyond 1.6× MIC.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00771-07

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