Affiliation:
1. Laboratory
of Molecular Biology, Medical Research Council, Cambridge CB2
2QH
2. Veterinary Sciences
Division, Department of Agriculture and Rural Development for
Northern Ireland, Stormont, Belfast BT4 3SD,
United Kingdom
Abstract
ABSTRACT
Circoviruses
are small, nonenveloped icosahedral animal viruses characterized by
circular single-stranded DNA genomes. Their genomes are the smallest
possessed by animal viruses. Infections with circoviruses, which can
lead to economically important diseases, frequently result in
virus-induced damage to lymphoid tissue and immunosuppression. Within
the family
Circoviridae
, different genera are distinguished by
differences in genomic organization. Thus,
Chicken
anemia virus
is in the genus
Gyrovirus
,
while porcine circoviruses and
Beak and
feather disease virus
belong to the genus
Circovirus
. Little is known about the structures of
circoviruses. Accordingly, we investigated the structures of these
three viruses with a view to determining whether they are related.
Three-dimensional maps computed from electron micrographs showed that
all three viruses have a T=1 organization with capsids formed
from 60 subunits. Porcine circovirus type 2 and beak and feather
disease virus show similar capsid structures with flat pentameric
morphological units, whereas chicken anemia virus has stikingly
different protruding pentagonal trumpet-shaped units. It thus appears
that the structures of viruses in the same genus are related but that
those of viruses in different genera are
unrelated.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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