Regulated Cleavage of Glycan Strands by the Murein Hydrolase SagB in Staphylococcus aureus Involves a Direct Interaction with LyrA (SpdC)-Reference-Cited by-同舟云学术

Regulated Cleavage of Glycan Strands by the Murein Hydrolase SagB in Staphylococcus aureus Involves a Direct Interaction with LyrA (SpdC)

Published:2021-04-08 Issue:9 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Willing Stephanie¹,Schneewind Olaf¹²,Missiakas Dominique¹²^ORCID

Affiliation:

1. Department of Microbiology, University of Chicago, Chicago, Illinois, USA

2. Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, Illinois, USA

Abstract

Peptidoglycan is assembled on the trans side of the plasma membrane from lipid II precursors into glycan chains that are cross-linked at stem peptides. In S. aureus , SagB, a membrane-associated N -acetylglucosaminidase, cleaves polymerized glycan chains to their physiological length.

Funder

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00014-21

Reference41 articles.

1. Structure of the Cell Wall of Staphylococcus aureus, Strain Copenhagen. II. Separation and Structure of Disaccharides

2. Formation of the glycan chains in the synthesis of bacterial peptidoglycan

3. Monofunctional Transglycosylases Are Not Essential for Staphylococcus aureus Cell Wall Synthesis