Affiliation:
1. Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
Abstract
ABSTRACT
Chlamydia trachomatis
is a Gram-negative obligate intracellular bacterial pathogen. It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections with
C. trachomatis
occurring each year. Animal models are indispensable for the study of
C. trachomatis
infections and the development and evaluation of candidate vaccines. In this paper, the most commonly used animal models to study female genital tract infections with
C. trachomatis
will be reviewed, namely, the mouse, guinea pig, and nonhuman primate models. Additionally, we will focus on the more recently developed pig model.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference112 articles.
1. WHO. 2012. Global incidence and prevalence of selected curable sexually transmitted infections – 2008. World Health Organization, Geneva, Switzerland.
2. CDC. December 2012. Sexually transmitted disease surveillance 2011 Division of STD Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA.
3. van de LaarMJMorreSA. 2007. Chlamydia: a major challenge for public health. Euro Surveill. 12(10):E1-2. http://www.ncbi.nlm.nih.gov/pubmed?term=Chlamydia%3A+a+major+challenge+for+public+health&TransSchema=title&cmd=detailssearch.
4. Etiology and clinical features of acute epididymo-orchitis;Ibrahim AA;Ann. Saudi Med.,1996
5. The role of Chlamydia trachomatis in genital-tract and associated diseases;Taylor-Robinson D;J. Clin. Pathol.,1980
Cited by
71 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献