In Vivo and In Vitro Studies of Antibiotic Release from and Bacterial Growth Inhibition by Antibiotic-Impregnated Polymethylmethacrylate Hip Spacers-Reference-Cited by-同舟云学术

In Vivo and In Vitro Studies of Antibiotic Release from and Bacterial Growth Inhibition by Antibiotic-Impregnated Polymethylmethacrylate Hip Spacers

Published:2006-01 Issue:1 Volume:50 Page:332-335
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kelm Jens¹,Regitz Thilo²,Schmitt Eduard¹,Jung Werner³,Anagnostakos Konstantinos¹

Affiliation:

1. Klinik für Orthopädie und Orthopädische Chirurgie, Homburg/Saar, Germany

2. Firma Regitz, Kirkel, Germany

3. Abteilung für Bakteriologie und Hygiene, Institut für Medizinische Mikrobiologie und Hygiene der Universitätskliniken des Saarlandes, Homburg/Saar, Germany

Abstract

ABSTRACT The antimicrobial properties and the elution characteristics of gentamicin-vancomycin-loaded hip spacers were studied in vivo and in vitro. Vancomycin elution was greater than gentamicin elution. The antibiotic concentrations in vivo were less than those in vitro. Not dependent on implantation duration, growth inhibition by spacers in vitro was observed for 2 weeks. The reason for protracted wound healing cannot be insufficient antibiotic release.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.1.332-335.2006

Reference15 articles.

1. Abendschein, W. 1992. Salvage of infected total hip replacement: use of antibiotic/PMMA-spacer. Orthopedics15:228-229.

2. Adams, K., L. Couch, G. Cierny, J. Calhoun, and J. T. Mader. 1992. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin. Orthop.278:244-252.

3. Anagnostakos, K., J. Kelm, T. Regitz, E. Schmitt, and W. Jung. 2005. In vitro evaluation of antibiotic release from and bacteria growth inhibition by antibiotic-loaded acrylic bone cement spacers. J. Biomed. Mater. Res. Part B Appl. Biomater.72:373-378.

4. Bertazzoni Minelli, E., A. Benini, B. Magnan, and P. Bartolozzi. 2004. Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty. J. Antimicrob. Chemother.53:329-334.

5. Duncan, C. P., and C. Beauchamp. 1993. A temporary antibiotic-loaded joint replacement system for management of complex infections involving the hip. Orthop. Clin. N. Am.24:751-759.

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