Induction of Native c-di-GMP Phosphodiesterases Leads to Dispersal of Pseudomonas aeruginosa Biofilms-Reference-Cited by-同舟云学术

Induction of Native c-di-GMP Phosphodiesterases Leads to Dispersal of Pseudomonas aeruginosa Biofilms

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Andersen Jens Bo¹,Kragh Kasper Nørskov¹^ORCID,Hultqvist Louise Dahl¹,Rybtke Morten¹,Nilsson Martin¹,Jakobsen Tim Holm¹,Givskov Michael¹²,Tolker-Nielsen Tim¹^ORCID

Affiliation:

1. Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore

Abstract

A decade of research has shown that the molecule c-di-GMP functions as a central second messenger in many bacteria. A high level of c-di-GMP is associated with biofilm formation, whereas a low level of c-di-GMP is associated with a planktonic single-cell bacterial lifestyle. c-di-GMP is formed by diguanylate cyclases and is degraded by specific phosphodiesterases.

Funder

Natur og Univers, Det Frie Forskningsråd

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02431-20

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