Influence of the Alternate Complement Pathway on Opsonization of Several Bacterial Species

Author:

Forsgren Arne1,Quie Paul G.1

Affiliation:

1. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Abstract

In normal human serum chelated with magnesium (10 mM) and ethylene glycotetraacetic acid (10 mM) (MgEGTA), the classical pathway of complement activation is blocked; however, the alternate pathway of complement activation is intact. Diplococcus pneumoniae, Staphylococcus albus, Streptococcus viridans, Streptococcus faecalis , and Serratia marcescens were opsonized in normal human serum containing 10 mM MgEGTA. In contrast, Staphylococcus aureus and Pseudomonas aeruginosa were poorly opsonized in human serum chelated with 10 mM MgEDTA. Therefore certain bacterial species appear to require the classical pathway of complement activation to be opsonized and other bacterial species utilize the alternate pathway of complement activation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference7 articles.

1. C3 shunt activation in human serum chelated with EGTA;Fine D. P.;J. Immunol.,1972

2. Opsonic activity in human sera chelated with ethylene glycotetracetic acid;Forsgren A.;Immunology,1974

3. Studies on heat-labile opsonin in rabbit serum;Hirsch J. G.;J. Immunol.,1964

4. Human heat-labile opsonins: evidence for their mediation via the alternate pathway of complement activation;Jasin H. E.;J. Immunol.,1972

5. Opsonic activity in human serum deficient in C2;Johnston F. R.;J. Immunol.,1972

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