Accuracy of Tongue Swab Testing Using Xpert MTB-RIF Ultra for Tuberculosis Diagnosis

Author:

Andama A.12,Whitman G. R.3ORCID,Crowder R.456,Reza T. F.456,Jaganath D.567,Mulondo J.2,Nalugwa T. K.4,Semitala F. C.12,Worodria W.18,Cook C.56,Wood R. C.3,Weigel K. M.3,Olson A. M.3,Lohmiller Shaw J.3,Kato-Maeda M.56,Denkinger C. M.910ORCID,Nahid P.456,Cangelosi G. A.3ORCID,Cattamanchi A.456ORCID

Affiliation:

1. Department of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda

2. Infectious Diseases Research Collaboration, Kampala, Uganda

3. Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA

4. Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda

5. Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA

6. Center for Tuberculosis, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA

7. Division of Pediatric Infectious Diseases, University of California San Francisco, San Francisco, California, USA

8. Mulago National Referral Hospital, Kampala, Uganda

9. Division of Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany

10. German Centre for Infection Research (DZIF) Partner Site, Heidelberg University Hospital, Heidelberg, Germany

Abstract

Tongue dorsum swabs have shown promise as alternatives to sputum for detecting Mycobacterium tuberculosis (MTB) in patients with pulmonary tuberculosis (TB). Some of the most encouraging results have come from studies that used manual quantitative PCR (qPCR) to analyze swabs.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | Fogarty International Center

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference18 articles.

1. World Health Organization. 2020. Global Tuberculosis Report 2020. World Health Organization, Geneva, Switzerland.

2. STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration

3. World Health Organization. 2015. The use of lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis and screening of active tuberculosis in people living with HIV: Policy guidance. https://apps.who.int/iris/handle/10665/193633.

4. Defining the Needs for Next Generation Assays for Tuberculosis

5. A Look Inside: Oral Sampling for Detection of Non-oral Infectious Diseases

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