Zebrafish Granulocyte Colony-Stimulating Factor Receptor Maintains Neutrophil Number and Function throughout the Life Span-Reference-Cited by-同舟云学术

Zebrafish Granulocyte Colony-Stimulating Factor Receptor Maintains Neutrophil Number and Function throughout the Life Span

Published:2019-02 Issue:2 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Basheer Faiza¹,Rasighaemi Parisa¹²,Liongue Clifford¹²,Ward Alister C.¹²^ORCID

Affiliation:

1. School of Medicine, Deakin University, Geelong, Victoria, Australia

2. Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia

Abstract

Granulocyte colony-stimulating factor receptor (G-CSFR), encoded by the CSF3R gene, represents a major regulator of neutrophil production and function in mammals, with inactivating extracellular mutations identified in a cohort of neutropenia patients unresponsive to G-CSF treatment. This study sought to elucidate the role of the zebrafish G-CSFR by generating mutants harboring these inactivating extracellular mutations using genome editing.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00793-18

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