Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels-Reference-Cited by-同舟云学术

Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels

Published:2016-03 Issue:3 Volume:23 Page:243-245
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Vissers Marloes¹,Ahout Inge M. L.¹,de Jonge Marien I.¹,Ferwerda Gerben¹

Affiliation:

1. Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

Abstract

ABSTRACT Maternal vaccination is currently considered a strategy against respiratory syncytial virus (RSV) infections. In RSV-infected infants, high mucosal IgG levels correlated better with reduced RSV load and lower mucosal CXCL10 levels than plasma IgG levels. For future vaccination strategies against RSV, more focus should be on the mucosal humoral immune response.

Funder

Dutch Government

Netherlands Genomics Iniative project

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00590-15

Reference15 articles.

1. Recovery of Cytopathogenic Agent from Chimpanzees with Goryza

2. ASSOCIATION OF A NEW TYPE OF CYTOPATHOGENIC MYXOVIRUS WITH INFANTILE CROUP