Kinetic interaction of biofilm cells of Staphylococcus aureus with cephalexin and tobramycin in a chemostat system-Reference-Cited by-同舟云学术

Kinetic interaction of biofilm cells of Staphylococcus aureus with cephalexin and tobramycin in a chemostat system

Published:1992-04 Issue:4 Volume:36 Page:890-893
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Anwar H¹,Strap J L¹,Costerton J W¹

Affiliation:

1. Department of Microbiology, University of Alberta, Edmonton, Canada.

Abstract

Planktonic and young biofilm cells were completely eradicated after exposure of these cells to drug levels representing one loading and two maintenance doses of tobramycin and cephalexin. A very different picture was observed when antibiotic exposure was initiated on day 21. Complete eradication of the old biofilm cells was not observed even when the antibiotic exposure was continued for an extra 6 days. Regrowth of the organism was observed when the antibiotic exposure was terminated.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.36.4.890

Reference21 articles.

1. Enhanced activity of combination of tobramycin and piperacillin for eradication of sessile biofilm cells of Pseudomonas aeruginosa;Anwar H.;Antimicrob. Agents Chemother.,1990

2. Testing the susceptibility of bacteria in biofilms to antibacterial agents;Anwar H.;Antimicrob. Agents Chemother.,1990

3. Tobramycin resistance of mucoid Pseudomonas aeruginosa biofilm grown under iron limitation;Anwar H.;J. Antimicrob. Chemother.,1989

4. Anwar H. J. L. Strap and J. W. Costerton. Eradication of biofilm cells of Staphylococcus aureus with tobramycin and cephalexin. Submitted for publication.

5. Interaction of biofilm bacteria with antibiotics in a novel in vitro chemostat system;Anwar H.;Antimicrob. Agents Chemother.,1989

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