Cell Cycle Kinase Polo Is Controlled by a Widespread 3′ Untranslated Region Regulatory Sequence in Drosophila melanogaster-Reference-Cited by-同舟云学术

Cell Cycle Kinase Polo Is Controlled by a Widespread 3′ Untranslated Region Regulatory Sequence in Drosophila melanogaster

Published:2019-08 Issue:15 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Oliveira Marta S.¹²³,Freitas Jaime¹²,Pinto Pedro A. B.¹²⁴,de Jesus Ana¹²,Tavares Joana⁵,Pinho Mafalda⁶⁷,Domingues Rita G.²⁸,Henriques Telmo²⁹,Lopes Carla²¹⁰,Conde Carlos²¹¹,Sunkel Claudio E.²¹¹¹²,Moreira Alexandra¹²¹²^ORCID

Affiliation:

1. Gene Regulation, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

2. Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

3. Programa Doutoral em Biologia Molecular e Celular, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal

4. Center for Organismal Studies Heidelberg, University of Heidelberg, Heidelberg, Germany

5. GenoMed-Diagnósticos de Medicina Molecular SA, Lisbon, Portugal

6. Tissue Morphogenesis and Repair Laboratory, CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal

7. Epithelial Polarity and Cell Division, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

8. Champalimaud Research, Champalimaud Center for the Unknown, Lisbon, Portugal

9. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

10. Neurodevelopment and Neurodegeneration, i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

11. Cell Division & Genomic Stability, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

12. Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal

Abstract

Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3′ untranslated region (3′UTR), with critical physiological consequences. Here, we characterized the molecular mechanisms required for polo alternative polyadenylation.

Funder

Fundo Europeu de Desenvolvimento Regional

Fundação para a Ciência e Tecnologia

Instituto de Ciências Biomédicas Abel Salazar

Norte Portugal Regional Operational Programme

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00581-18

Reference93 articles.