Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates-Reference-Cited by-同舟云学术

Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates

Published:2022-05-17 Issue:5 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Karabasevic Natalija¹^ORCID,Roberts Jason A.²³⁴⁵^ORCID,Stronach Luke²,Naicker Saiyuri²³,Wallis Steven C.³,Sjövall Fredrik⁶⁷,Sime Fekade²³^ORCID

Affiliation:

1. Medical Programme, Faculty of Medicine, Lund University, Lund, Sweden

2. Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia

3. The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia

4. Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

5. Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France

6. Department of Intensive Care and Perioperative Medicine, Skane University Hospital, Malmö, Sweden

7. Mitochondrial Medicine, Lund University, Lund, Sweden

Abstract

Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ∼ 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 10 8 – 10 10 CFU/mL at 120 h.

Funder

Practitioner Fellowship

Advancing Queensland Clinical Fellowship

Swedish Research Council

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02140-21

Reference23 articles.

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