Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Thakur Preeti¹^ORCID,Sutiwisesak Rujapak¹²³,Lu Yu-Jung¹²,Behar Samuel M.¹²^ORCID

Affiliation:

1. Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

2. Immunology and Microbiology Program, Graduate School of Biomedical Science, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

3. Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand

Abstract

Human CD8 T cells express the antimicrobial peptide granulysin in their cytotoxic granules, andin vitroanalysis suggest that it restricts growth ofMycobacterium tuberculosisand other intracellular pathogens. The murine model of tuberculosis cannot assess granulysin’s rolein vivo, as rodents lack the granulysin gene.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03020-22

Reference37 articles.

1. The Expanding Arsenal of Cytotoxic T Cells

2. Distinct roles of cytolytic effector molecules for antigen‐restricted killing by CTL in vivo

3. Mycobacterium tuberculosis-Specific CD8+T Cells Require Perforin to Kill Target Cells and Provide Protection In Vivo

4. Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules

5. Distinct T cell receptor signaling requirements for perforin- or FasL-mediated cytotoxicity.

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