Th17 T Cells and Immature Dendritic Cells Are the Preferential Initial Targets after Rectal Challenge with a Simian Immunodeficiency Virus-Based Replication-Defective Dual-Reporter Vector-Reference-Cited by-同舟云学术

Th17 T Cells and Immature Dendritic Cells Are the Preferential Initial Targets after Rectal Challenge with a Simian Immunodeficiency Virus-Based Replication-Defective Dual-Reporter Vector

Published:2021-09-09 Issue:19 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Maric Danijela¹,Grimm Wesley A.¹,Greco Natalie¹,McRaven Michael D.¹,Fought Angela J.¹,Veazey Ronald S.²,Hope Thomas J.¹^ORCID

Affiliation:

1. Northwestern University Feinberg School of Medicine, Department of Cell and Developmental Biology, Chicago, Illinois, USA

2. Tulane National Primate Research Center, Division of Comparative Pathology, Covington, Louisiana, USA

Abstract

Men and women who participate in unprotected receptive anal intercourse are at high risk of acquiring HIV. While in vitro data have developed a framework for understanding HIV cell tropism, the initial target cells in the rectal mucosa have not been identified.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00707-21

Reference48 articles.

1. HIV infection — United States, 2008 and 2010;Johnson AS;MMWR Suppl,2013

2. Vaginal Challenge with an SIV-Based Dual Reporter System Reveals That Infection Can Occur throughout the Upper and Lower Female Reproductive Tract

3. Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques