Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole l -Riboside 1263W94-Reference-Cited by-同舟云学术

Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole l -Riboside 1263W94

Published:2001-11 Issue:6 Volume:8 Page:1279-1281
ISSN:1071-412X
Container-title:Clinical Diagnostic Laboratory Immunology
language:en
Short-container-title:Clin Diagn Lab Immunol

Author:

McSharry James J.¹,McDonough Ann¹,Olson Betty¹,Talarico Christine²,Davis Michele²,Biron Karen K.²

Affiliation:

1. Albany Medical College, Albany, New York,1 and

2. GlaxoSmithKline, Research Triangle Park, North Carolina2

Abstract

ABSTRACT The average 50% inhibitory concentration (IC 50 ) values for AD169 were 0.22 ± 0.09 μM 1263W94 and 5.36 ± 0.12 μM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC 50 was 0.42 ± 0.09 μM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC 50 was 3.78 ± 1.62 μM ganciclovir. Nine HCMV clinical isolates that were resistant to ganciclovir were completely susceptible to 1263W94.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.8.6.1279-1281.2001

Reference23 articles.

1. Britt W. J. Alford C. A. Cytomegalovirus P. 2493–2524. Fields virology 3rd ed. Fields B. N. Knipe D. M. Howley P. M. 1996 Lippincott-Raven Publishers Philadelphia Pa

2. Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.;Chou S.;J. Infect. Dis.,1995

3. Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates.;Chou S.;J. Infect. Dis.,1995

4. Development of novel benzimidazole riboside compounds for treatment of cytomegalovirus disease.;Chulay J.;Adv. Exp. Med. Biol.,1999

5. Ganciclovir.;Crumpacker C.;N. Engl. J. Med.,1996

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