A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection-Reference-Cited by-同舟云学术

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rubione Julia¹²^ORCID,Pérez Paula S.¹²^ORCID,Czernikier Alejandro¹²,Duette Gabriel A.¹²,Pereyra Gerber Federico Pehuen¹²,Salido Jimena¹²,Fabiano Martina P.¹²,Ghiglione Yanina¹²,Turk Gabriela¹²,Laufer Natalia¹²,Cagnoni Alejandro J.³⁴,Pérez Sáez Juan M.⁴,Merlo Joaquín P.³,Pascuale Carla¹²,Stupirski Juan C.⁴,Sued Omar⁵,Varas-Godoy Manuel⁶,Lewin Sharon R.⁷⁸⁹,Mariño Karina V.³^ORCID,Rabinovich Gabriel A.⁴¹⁰,Ostrowski Matías¹²^ORCID

Affiliation:

1. Facultad de Medicina, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

2. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

3. Laboratorio de Glicómica Funcional y Molecular, Instituto de Biología y Medicina Experimental (IBYME—CONICET), Buenos Aires, Argentina

4. Laboratorio de Glicomedicina, Instituto de Biología y Medicina Experimental (IBYME—CONICET), Buenos Aires, Argentina

5. Fundación Huésped, Buenos Aires, Argentina

6. Cancer Cell Biology Lab, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile

7. The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Victoria, Australia

8. Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

9. Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, Victoria, Australia

10. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

Abstract

Antiretroviral therapy has led to a dramatic reduction in HIV-related morbidity and mortality. However, cART does not eradicate the virus, which persists in resting CD4+T cells as the main viral reservoir, consequently requiring lifelong treatment.

Funder

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute on Drug Abuse

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00611-22

Reference97 articles.

1. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation