Antibiotic Resistance via Bacterial Cell Shape-Shifting

Author:

Ojkic Nikola12,Serbanescu Diana1,Banerjee Shiladitya3ORCID

Affiliation:

1. Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, United Kingdom

2. School of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom

3. Department of Physics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

Abstract

Bacteria have evolved to develop multiple strategies for antibiotic resistance by effectively reducing intracellular antibiotic concentrations or antibiotic binding affinities, but the role of cell morphology in antibiotic resistance remains poorly understood. By analyzing cell morphological data for different bacterial species under antibiotic stress, we find that bacteria increase or decrease the cell surface-to-volume ratio depending on the antibiotic target.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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