Tryptophan Operon Diversity Reveals Evolutionary Trends among Geographically Disparate Chlamydia trachomatis Ocular and Urogenital Strains Affecting Tryptophan Repressor and Synthase Function-Reference-Cited by-同舟云学术

Tryptophan Operon Diversity Reveals Evolutionary Trends among Geographically Disparate Chlamydia trachomatis Ocular and Urogenital Strains Affecting Tryptophan Repressor and Synthase Function

Published:2021-05-11 Issue: Volume: Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Bommana Sankhya¹,Somboonna Naraporn²,Richards Gracie¹,Tarazkar Maryam¹,Dean Deborah¹²³⁴^ORCID

Affiliation:

1. Department of Pediatrics, University of California San Francisco, Oakland, California, USA

2. Department of Bioengineering, Joint Graduate Program, University of California San Francisco and University of California Berkeley, San Francisco, California, USA

3. Department of Medicine, University of California San Francisco, San Francisco, California, USA

4. Bixby Center for Global Reproductive Health, University of California San Francisco, San Francisco, California, USA

Abstract

Chlamydia trachomatis ( Ct ) is a major global public health concern causing sexually transmitted and ocular infections affecting over 130 million and 260 million people, respectively. Sequelae include infertility, preterm birth, ectopic pregnancy, and blindness. Ct relies on available host tryptophan pools and/or substrates to synthesize tryptophan to survive.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00605-21

Reference84 articles.

1. WHO. 2018. Report on global sexually transmitted infection surveillance. World Health Organization, Geneva, Switzerland.

2. Bennett JE, Dolin R, Blaser MJ. 2016. Douglas and Bennett’s infectious diseases essentials. Elsevier Inc, Philadelphia, PA.

3. Lymphogranuloma venereum among men who have sex with men. An epidemiological and clinical review

4. Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing

5. WHO. 2019. Trachoma epidemiologic situation. World Health Organization, Geneva, Switzerland.

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Metabolism and physiology of pathogenic bacterial obligate intracellular parasites;Frontiers in Cellular and Infection Microbiology;2024-03-22

2. Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny;Frontiers in Cellular and Infection Microbiology;2023-05-23

3. Association of Chlamydia trachomatis and Neisseria gonorrhoeae with female infertility: a systematic review and meta-analysis;UNIVERSA MED;2022

4. Alterations in the vaginal microbiota of patients with preterm premature rupture of membranes;Frontiers in Cellular and Infection Microbiology;2022-08-08

5. The role of tryptophan in Chlamydia trachomatis persistence;Frontiers in Cellular and Infection Microbiology;2022-08-02