Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7-Reference-Cited by-同舟云学术

Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7

Published:2017-09 Issue:9 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bauwens Andreas¹,Kunsmann Lisa¹,Karch Helge¹²,Mellmann Alexander¹²^ORCID,Bielaszewska Martina¹

Affiliation:

1. Institute for Hygiene, University of Münster, Münster, Germany

2. Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany

Abstract

ABSTRACT Ciprofloxacin, meropenem, fosfomycin, and polymyxin B strongly increase production of outer membrane vesicles (OMVs) in Escherichia coli O104:H4 and O157:H7. Ciprofloxacin also upregulates OMV-associated Shiga toxin 2a, the major virulence factor of these pathogens, whereas the other antibiotics increase OMV production without the toxin. These two effects might worsen the clinical outcome of infections caused by Shiga toxin-producing E. coli . Our data support the existing recommendations to avoid antibiotics for treatment of these infections.

Funder

Interdisciplinary Center for Clinical Research

Deutsche Forschungsgemeinschaft

European Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00937-17

Reference29 articles.

1. Enterohaemorrhagic Escherichia coli in human medicine