Identification of a 1.4-kb-Long Sequence Located in the nsp12 and nsp13 Coding Regions of SARS-CoV-2 Genomic RNA That Mediates Efficient Viral RNA Packaging-Reference-Cited by-同舟云学术

Identification of a 1.4-kb-Long Sequence Located in the nsp12 and nsp13 Coding Regions of SARS-CoV-2 Genomic RNA That Mediates Efficient Viral RNA Packaging

Published:2023-07-27 Issue:7 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Terasaki Kaori¹²^ORCID,Narayanan Krishna¹,Makino Shinji¹²³⁴⁵^ORCID

Affiliation:

1. Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA

2. Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, Texas, USA

3. Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas, USA

4. UTMB Center for Tropical Diseases, The University of Texas Medical Branch, Galveston, Texas, USA

5. The Sealy Institute for Vaccine Sciences, The University of Texas Medical Branch, Galveston, Texas, USA

Abstract

Elucidating the mechanism of SARS-CoV-2 RNA packaging into virus particles is important for the rational design of antiviral drugs that inhibit this vital step in the replication cycle of CoVs. However, our knowledge about the RNA packaging mechanism in SARS-CoV-2, including the identification of the viral RNA region important for SARS-CoV-2 RNA packaging, is limited, primarily due to the logistical challenges of handing SARS-CoV-2 in biosafety level 3 (BSL3) facilities.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00659-23

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