Novel 3- N -Aminoglycoside Acetyltransferase Gene, aac ( 3 )- Ic , from a Pseudomonas aeruginosa Integron-Reference-Cited by-同舟云学术

Novel 3- N -Aminoglycoside Acetyltransferase Gene, aac ( 3 )- Ic , from a Pseudomonas aeruginosa Integron

Published:2003-05 Issue:5 Volume:47 Page:1746-1748
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Riccio Maria Letizia¹,Docquier Jean-Denis¹,Dell'Amico Emanuela¹,Luzzaro Francesco²,Amicosante Gianfranco³,Rossolini Gian Maria¹

Affiliation:

1. Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena

2. Laboratorio di Microbiologia, Ospedale di Circolo di Varese, I-21100, Varese

3. Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, I-67100, L'Aquila, Italy

Abstract

ABSTRACT A novel gene, aac ( 3 )- Ic , encoding an AAC(3)-I aminoglycoside 3- N -acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a bla VIM-2 and a cmlA7 gene cassette. The aac ( 3 )- Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.5.1746-1748.2003

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