Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection-Reference-Cited by-同舟云学术

Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection

Published:2020-04-28 Issue:2 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Li Kun¹,Li Zhuo²,Wohlford-Lenane Christine¹,Meyerholz David K.³,Channappanavar Rudragouda⁴,An Dong²,Perlman Stanley¹⁴^ORCID,McCray Paul B.¹⁴,He Biao²

Affiliation:

1. Department of Pediatrics, Pappajohn Biomedical Institute, University of Iowa, Iowa City, Iowa, USA

2. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA

3. Department of Pathology, University of Iowa, Iowa City, Iowa, USA

4. Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA

Abstract

MERS-CoV causes lethal infection in humans, and there is no vaccine. Our work demonstrates that PIV5 is a promising vector for developing a MERS vaccine. Furthermore, success of PIV5-based MERS vaccine can be employed to develop a vaccine for emerging CoVs such as SARS-CoV-2, which causes COVID-19.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Cystic Fibrosis Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00554-20

Reference53 articles.

1. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia