Affiliation:
1. Department of Microbiology, New York University School of Medicine, New York, New York 10016
Abstract
An episome, F32, which carries the genetic markers
dsdA
+
, the presumed structural gene for
d
-serine deaminase,
dsdC
+
, a regulatory locus governing the synthesis of
d
-serine deaminase,
aroC
+
, and
purC
+
was obtained from strain AB311 of
Escherichia coli
K-12, and was used to construct appropriate merodiploids with
dsdC
markers. In all
dsdC
/
dsdC
+
diploids examined,
dsdC
was found to be
cis
dominant,
trans
recessive, to
dsdC
+
. In two cases, however, the
cis
dominance was only partial. Moreover, complementation was observed between one of the
dsdC
markers which is fully
cis
dominant and one which is partially
cis
dominant. Because of the size of the
dsdC
region, the phenotypes of the mutants, and the partial
trans
dominance of
dsdC
+
over some of the
dsdC
mutations, it is suggested that the
dsdC
region specifies a product, but that this product does not move with facility through the cytoplasm
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
31 articles.
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