Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques-Reference-Cited by-同舟云学术

Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques

Published:2019-01-15 Issue:2 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lo Ming¹²,Zhu Jia³⁴,Hansen Scott G.⁵⁶,Carroll Timothy¹²,Farr Zuend Christina⁷⁸,Nöel-Romas Laura⁷⁸,Ma Zhong-Min¹²,Fritts Linda¹²,Huang Meei-Li³,Sun Sijie³,Huang Ying³,Koelle David M.³⁴⁹,Picker Louis J.⁵⁶,Burgener Adam⁷⁸¹⁰,Corey Lawrence³⁴⁹,Miller Christopher J.¹²

Affiliation:

1. Center for Comparative Medicine, University of California Davis, Davis, California, USA

2. California National Primate Research Center, University of California Davis, Davis, California, USA

3. Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA

4. Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

5. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA

6. Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

7. National HIV and Retrovirology Labs, J.C. Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

8. University of Manitoba, Winnipeg, Manitoba, Canada

9. Department of Medicine, University of Washington, Seattle, Washington, USA

10. Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

Abstract

Herpes simplex virus 2 (HSV-2) infects nearly 500 million persons globally, with an estimated 21 million incident cases each year, making it one of the most common sexually transmitted infections (STIs). HSV-2 is associated with increased human immunodeficiency virus type 1 (HIV-1) acquisition, and this risk does not decline with the use of antiherpes drugs. As initial acquisition of both HIV and HSV-2 infections is subclinical, study of the initial molecular interactions of the two agents requires an animal model. We found that HSV-2 can infect RM after vaginal inoculation, establish latency in the nervous system, and spontaneously reactivate; these features mimic some of the key features of HSV-2 infection in women. RM may provide an animal model to develop strategies to prevent HSV-2 acquisition and reactivation.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01574-18

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