Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike Protein

Author:

Chen Yuliu1,Wu Yan2,Chen Shaoying1,Zhan Qingping1,Wu Dingzhou1,Yang Chan1,He Xiaoxue2,Qiu Mengjie1,Zhang Nannan3,Li Zhaofeng1,Guo Yunhua4,Wen Minjun1,Lu Lu5,Ma Cuiqing6,Guo Jiayin1,Xu Wei1,Li Xiaojuan1,Li Lin1ORCID,Jiang Shibo5,Pan Xiaoyan2,Liu Shuwen1ORCID,Tan Suiyi1ORCID

Affiliation:

1. NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China

2. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

3. Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

4. Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

5. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science and Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

6. Department of Immunology, Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, China

Abstract

The study shows SRT is an effective entry inhibitor against infection of SARS-CoV-2, which is currently prevalent globally. SRT targets the S protein of SARS-CoV-2 and is effective against a panel of SARS-CoV-2 variants.

Funder

Prevention and Treatment of COVID-19 Scientifif and Technological Special Projects of Guangdong Province

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3