Differential Recognition of Computationally Optimized H3 Hemagglutinin Influenza Vaccine Candidates by Human Antibodies-Reference-Cited by-同舟云学术

Differential Recognition of Computationally Optimized H3 Hemagglutinin Influenza Vaccine Candidates by Human Antibodies

Published:2022-08-24 Issue:16 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Abbadi Nada¹²,Nagashima Kaito¹²,Pena-Briseno Alma²,Ross Ted M.¹²^ORCID,Mousa Jarrod J.¹²³^ORCID

Affiliation:

1. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA

2. Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA

3. Department of Biochemistry and Molecular Biology, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, USA

Abstract

Vaccine development for circulating influenza viruses, particularly for the H3N2 subtype, remains challenging due to consistent antigenic drift. Computationally optimized broadly reactive antigen (COBRA) technology has proven effective for broadening influenza hemagglutinin (HA)-elicited antibody responses compared to wild-type immunogens.

Funder

Georgia Research Alliance

HHS | NIH | NIH Office of the Director

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00896-22

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1. 1918 Influenza: the Mother of All Pandemics