Subcellular localization of the human immunodeficiency virus trans-acting art gene product-Reference-Cited by-同舟云学术

Subcellular localization of the human immunodeficiency virus trans-acting art gene product

Published:1988-07 Issue:7 Volume:62 Page:2498-2501
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cullen B R¹,Hauber J¹,Campbell K¹,Sodroski J G¹,Haseltine W A¹,Rosen C A¹

Affiliation:

1. Department of Molecular Genetics, Hoffman-La Roche, Inc., Nutley, New Jersey 07110.

Abstract

The genome of the human immunodeficiency virus is distinguished from other animal retroviruses by the presence of several additional open reading frames. The protein product of one of these novel genes, which has been termed art or trs, is required for the expression of the virus structural genes but not for the expression of virus encoded regulatory proteins. Immunocytochemistry and subcellular fractionation demonstrate that the art protein is located predominantly in the nucleus. Therefore, any proposed mechanism for the function of art is likely to involve nuclear events.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.62.7.2498-2501.1988

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